Antibiotics Orals

Product Details:

Indications:    

Clindamycin is indicated for the treatment of:

• Serious infections caused by anaerobic bacteria, including intra-abdominal infections, skin and soft tissue infections. As needed, clindamycin should be administered in conjunction with another antibacterial agent that is active against gram negative aerobic bacteria.
• Tonsillitis
• Dental infection
• Consideration should be given to the official guidance on the appropriate use of antibacterial agents

Dosage:
Adults

• The usual dose is 150-450 mg every six hours, depending on the severity of the infection.

Elderly patients

• Dosage requirements in elderly patients should not be influenced by age alone

Pediatric population

• The usual dose is 3-6 mg/kg every six hours depending on the severity of the infection (not to exceed the adult dose).
• Clindamycin capsules are not suitable for children who are unable to swallow them whole. The capsules do not provide exact mg/kg doses therefore it may be necessary to use an alternative formulation in some cases.

Product Details:

Indications:    

• Amoebiasis   
• Trichomoniasis
• Giardiasis   
• Bacterial vaginosis
• Acute necrotising ulcerative gingivitis   
• Anaerobic bacterial infectionsProphylaxis of postoperative anaerobic bacterial infections   
• Eradication of H. pylori associated with peptic ulcer disease
• Leg ulcers and pressure sores   
• Acute dental infections

Dosage:

Amoebiasis

• Adult: 800 mg bid for 5 days (intestinal infection); 5-10 days (extra-intestinal
• infection). Max: 2.4 g/day.
• Child: 1-3 yr 100-200 mg bid; >3-7 yr 100-200 mg 4 times daily; >7-10 yr 200-
• 400 mg tid. Doses are given for 5-10 days.

Trichomoniasis

• Adult: 2 g as a single dose, 200 mg bid for 7 days or 400 mg bid for 5-7 days.
• Partners should also be treated. Repeat treatment 4-6 wk between courses as necessary.
• Child: 1-10 yr 40 mg/kg as a single dose or 15-30 mg/kg daily in 2-3 divided doses for 7 days. Max: 2 g/dose.

Giardiasis

• Adult: 2 g once daily for 3 days, 400 mg bid for 5 days or 500 mg bid for 7-10 days.
• Child: 1-3 yr 500 mg once daily; >3-7 yr 600-800 mg once daily; >7-10 yr 1 gonce daily. Doses are given for 3 days.

Bacterial vaginosis

• Adult: 2 g as a single dose or 400 mg bid for 5-7 days.

Acute necrotising ulcerative gingivitis

• Adult: 200 mg tid for 3 days.
• Child: 1-3 yr 50 mg tid; >3-7 yr 100 mg bid; >7-10 yr 100 mg tid. Doses are given for 3 days.

Anaerobic bacterial infections

• Adult: Initially, 800 mg followed by 400 mg 8 hrly. Alternatively, 7.5 mg/kg 6-8 hrly. Max: 4 g/day. Duration of treatment is usually for 7 days depending on the severity of infection.
• Child: <8 wk 7.5 mg/kg 12 hrly or 15 mg/kg once daily. 8 wk to 12 yr 7.5 mg/kg 8 hrly or 20-30 mg/kg once daily. Duration of treatment is usually for 7 days depending on the severity of infection.

Prophylaxis of postoperative anaerobic bacterial infections

• Adult: 400 mg 8 hrly 24 hr prior to surgery followed by post-op IV or rectal admin until oral therapy is possible.
• Child: <40 wk 10 mg/kg as a single dose before surgery; <12 yr 20-30 mg/kg as a single dose 1-2 hr before surgery.

Eradication of H. pylori associated with peptic ulcer disease

• Adult: 400 mg bid in combination w/ another antibacterial and a PPI or 400 mg tid, if given w/ omeprazole and amoxicillin. Initial treatment is given for 1 wk.

Leg ulcers and pressure sores

• Adult: 400 mg tid for 7 days.

Acute dental infections

• Adult: 200 mg tid for 3-7 days.

Product Details:

Indications:    

• Community-acquired pneumonia,
• Acute bacterial exacerbation of chronic

Dosage:

• Adult: 100-300 mg daily, as a single dose or 2 divided doses

Product Details:

Indications:    

• Respiratory tract infections
• Skin and soft tissue infections
• Susceptible infections
• Eradication of H. pylori associated with peptic ulcer disease

Dosage:

Respiratory tract infections, Skin and soft tissue infections, Susceptible infections

• Adult: 250 mg bid, increased to 500 mg bid for severe infections, if necessary, for 7-14 days.
• Child: 7.5 mg/kg bid for 5-10 days.

Eradication of H. pylori associated with peptic ulcer disease

• Adult: 500 mg bid, in combination w/ another antibacterial and either a PPI or H2-receptor antagonist for 7-14 days.
• Child: ≥1 yr 7.5 mg/kg bid, may be given w/ another antibacterial and a PPI for 7 days.

Product Details:

Indications:

• Otitis media
• Respiratory tract infections
• Urinary tract infections
• Uncomplicated gonorrhoea

Dosage:

Otitis media; Respiratory tract infections; Urinary tract infections:

• Adult: 375-750 mg bid.
• Child: <30 kg: 25-50 mg/kg/day in 2 divided doses. ≥30 kg: same as adult dose.

Uncomplicated gonorrhoea

• Adult: 2.25 g as single dose, together with 1 g probenecid.

Product Details:

Indications:

• Roxithromycin is a macrolide antibiotic. It is used in the treatment of respiratory tract, urinary and soft tissue infections, pneumonia (lung infection), skin infection and infection of the.

Dosage:

• Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections.
• Child: 6-40 kg: 5-8 mg/kg daily.

Product Details:

Indications:

• Vaginal candidiasis

Dosage:

500 mg vaginal tablet

• Adult: one vaginal tablet at bedtime, single dose.

100 mg vaginal tablet

• Adult: one vaginal tablet once daily at bedtime for 6 days.

Product Details:

Indications:    

• Anaerobic infections
• Respiratory tract  infections
• Skin  infections
• Soft tissue  infections
• Staphylococcal bone and joint infections
• Peritonitis
• Endocarditis prophylaxis

Dosage:
 
Oral

Serious anaerobic infections

• Adult: 150-300 mg 6 every hr; for more severe infection: 300 to 450 mg every 6 hr.
• Child: 2-4 mg/kg every 6 hr; for more severe infection: 3-6 mg/kg every 6 hr; 10 kg: 37.5 mg every 8hr.

Prophylaxis of endocarditis 600 mg 1 hr before dental procedure.

Intravenous/Intramuscular:
Serious anaerobic infections

• Adult: 0.6-2.7 g/day in 3-4 divided doses, up to 4.8 g/day for severe infections.
• Child: 20-40 mg/kg daily in 3-4 divided dose.
• Neonate: 15-20 mg/kg daily in 3-4 divided dose.

Toxic shock syndrome

• Adult: 900 mg every 8 hr along with penicillin G or ceftriaxone.

Pelvic inflammatory disease

• Adult: 900 mg every 8 hr along with gentamicin.

Vaginal

Bacterial vaginosis

• As pessary or 2% cream: 100 mg once nightly for 3-7 days.

Topical Acne

• As 1% preparation: Apply twice daily.

Product Details:

Indications:    

• Lower respiratory tract infections   
• Skin and soft tissue infections
• Upper respiratory tract infections   
• Cystitis
• Cervicitis   
• Gonococcal urethritis
• Pyelonephritis   
• ProstatitisPelvic inflammatory disease   
• Treatment and postexposure prophylaxis of inhalation anthrax
• Bone and joint infections   
• Typhoid fever
• Intra-abdominal infections   

Dosage:

Lower respiratory tract infections, Skin and soft tissue infections, Upper respiratory tract infections:

• Adult: 500-750 mg bid for 7-14 days. Malignant external otitis: 750 mg bid for 28 days to 3 mth.

Cystitis

• Adult: Uncomplicated: 250-500 mg bid for 3 days; pre-menopausal women: 500 mg as a single dose. Complicated: 500 mg bid for 7 days.

Cervicitis

• Adult: 500 mg as a single dose.

Gonococcal urethritis

• Adult: 500 mg as a single dose.

Pyelonephritis

• Adult: Uncomplicated: 500 mg bid for 7 days. Complicated: 500-750 mg bid for at least 10 days; can be continued for >21 days in specific circumstances
• Child: ≥1 yr 10-20 mg/kg body wt bid for 10-21 days. Max: 750 mg/dose.

Prostatitis

• Adult: 500-750 mg bid for 2-4 wk (acute) or 4-6 wk (chronic).

Pelvic inflammatory disease

• Adult: 500-750 mg bid for at least 14 days.

Treatment and postexposure prophylaxis of inhalation anthrax

• Adult: 500 mg bid 60 days from confirmation of Bacillus anthracis exposure.
• Child: 10-15 mg/kg body wt bid 60 days from confirmation of Bacillus anthracis exposure. Max: 500 mg/dose.

Bone and joint infections

• Adult: 500-750 mg bid to max 3 mth.

Diarrhoea

• Adult: 500 mg bid for 1-5 days depending on the severity and nature of infection.

Typhoid fever

• Adult: 500 mg bid for 7 days.

Intra-abdominal infections

• Adult: 500-750 mg bid for 5-14 days.

Product Details:

Indications:

• Skin and soft tissue infections
• Uncomplicated urinary tract infections
• Bone and joint infections
• Respiratory tract infections
• Streptococcal pharyngitis
• Otitis media

Dosage:

Skin and soft tissue infections:

• Adult: 500 mg 12 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Uncomplicated urinary tract infections:

• Adult: 500 mg 12 hrly for 7-14 days. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Bone and joint infections:

• Adult: 250 mg 6 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Respiratory tract infections:

• Adult: 250 mg 6 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Streptococcal pharyngitis:

• Adult: 500 mg 12 hrly for at least 10 days. Max: 4 g/day in divided doses.
• Child: >1 yr 25-50 mg/kg/day in divided doses 12 hrly for at least 10 days.

Otitis media:

• Child: 75-100 mg/kg/day in 4 divided doses.

Product Details:

Indications:

• Acute exacerbations of chronic bronchitis
• Acute otitis media
• Urinary tract infections
• Pneumocystis (carinii) jiroveci pneumonia
• Prophylaxis of Pneumocystis(carinii) jiroveci pneumonia

Dosage:

Acute exacerbations of chronic bronchitis; Acute otitis media; Urinary tract infections:

• Adult: Each tab contains sulfamethoxazole 400 mg or 800 mg and trimethoprim 80 mg or 160 mg; each 5 mL of oral susp contains sulfamethoxazole 200 mg and trimethoprim 40 mg: 960 mg bid. Severe infections: 2.88 g daily in 2 divided doses.
• Child: 6 wk to 5 mth 120 mg bid; 6 mth to 5 yr 240 mg bid; 6-11 yr 480 mg bid.

Pneumocystis (carinii) jiroveci pneumonia:

• Adult: Each tab contains sulfamethoxazole 400 mg or 800 mg and trimethoprim 80 mg or 160 mg; each 5 mL of oral susp contains sulfamethoxazole 200 mg and trimethoprim 40 mg: 120 mg/kg daily in 2-4 divided doses for 14-21 days.
• Child: ≥4 wk Same as adult dose.

Prophylaxis of Pneumocystis(carinii) jiroveci pneumonia:

• Adult: Each tab contains sulfamethoxazole 400 mg or 800 mg and trimethoprim 80 mg or 160 mg; each 5 mL of oral susp contains sulfamethoxazole 200 mg and trimethoprim 40 mg: 960 mg once daily for 7 days; 960 mg once daily 3 times wkly on alternate days; or 960 mg bid 3 times wkly on alternate days.
• Child: ≥4 wk 15-30 mg/kg bid, 2-3 times wkly given on consecutive or alternate days.

Product Details:

Indications:

• Uncomplicated gonorrhoea
• Pelvic inflammatory disease
• Urinary tract infections
• Prostatitis
• Lower respiratory tract infections
• Skin and soft tissue infections
• Uncomplicated genital infections due to Chlamydia trachomatis
• Non-gonococcal cervicitis/urethritis due to Chlamydia trachomatis

Dosage:

Uncomplicated gonorrhea

• Adult: 400 mg as a single dose.

Pelvic inflammatory disease

• Adult: 400 mg bid for 14 days.

Urinary tract infections

• Adult: 200-400 mg daily preferably in the morning. If necessary, increase in upper UTI to 400 mg bid.

Prostatitis

• Adult: Acute or chronic: 200 mg bid for 28 days.

Lower respiratory tract infections

• Adult: 400 mg daily preferably in the morning, increased to 400 mg bid as required.

Skin and soft tissue infections

• Adult: 400 mg bid.

Uncomplicated genital infections due to Chlamydia trachomatis; Non-gonococcal cervicitis/urethritis due to Chlamydia trachomatis:

• Adult: 400 mg daily in single or divided doses for 7 days

Product Details:

Indications:    

• Respiratory tract infections
• Skin and soft tissue infections
• Susceptible infections
• Acne
• Prophylaxis of streptococcal infections in patients with evidence of rheumatic fever or heart disease

Dosage:

Respiratory tract infections; Skin and soft tissue infections; Susceptible infections

• Adult: 1-2 g daily, in 2-4 divided doses, increased up to 4 g daily for severe infections. Doses >1 g should be given in more than 2 divided doses.
• Child: 30-50 mg/kg daily, in 2-4 divided doses, may be doubled in severe cases. <2 yr 500 mg daily in divided doses; 2-8 yr 1 g daily in divided doses.
• Acne: Adult: 250 mg daily. Severe cases may require up to 500 mg bid.

Prophylaxis of streptococcal infections in patients with evidence of rheumatic fever  or heart disease:

• Adult: For patients who are unable to take penicillins or sulfonamides: 250 mg bid.
• Child: For patients who are unable to take penicillins or sulfonamides: 1 mth to 2 yr 125 mg bid.

Product Details:

Indications:    

• Uncomplicated skin and skin structure infections
• Vancomycin-resistant Enterococcus faecium
• Methicillin-resistant Staphylococcus aureus infections
• Community-acquired pneumonia
• Nosocomial pneumonia
• Complicated skin and skin structure infections

Dosage:

Uncomplicated skin and skin structure infections

• Adult: 400 mg 12 hrly for 10-14 days.
• Child: <5 yr 10 mg/kg 8 hrly; 5-11 yr 10 mg/kg 12 hrly; ≥12 yr 600 mg 12 hrly.
• All doses to be taken for 10-14 days.
• Elderly: No dosage adjustment needed.

Vancomycin-resistant Enterococcus faecium

• Adult: 600 mg 12 hrly for 14-28 days.
• Child: <7 days 10 mg/kg 12 hrly, may increase to 10 mg/kg 8 hrly depending on clinical response; 7 days to 11 yr 10 mg/kg 8 hrly; ≥12 yr 600 mg 12 hrly. All
• Doses to be taken for 14-28 days.
• Elderly: No dosage adjustment needed.

Methicillin-resistant Staphylococcus aureus infections

• Adult: 600 mg bid for 7-21 days.
• Elderly: No dosage adjustment needed.

Community-acquired pneumonia; Nosocomial pneumonia; Complicated skin and skin structure infections:

• Adult: 600 mg 12 hrly for 10-14 days.
• Child: <7 days 10 mg/kg 12 hrly, may increase to 10 mg/kg 8 hrly depending on clinical response; 7 days to 11 yr 10 mg/kg 8 hrly; ≥12 yr 600 mg 12 hrly. All
• Doses to be taken for 10-14 days.
• Elderly: No dosage adjustment needed.

Product Details:

Indications:

• Uncomplicated gonorrhoea
• Pelvic inflammatory disease
• Urinary tract infections
• Prostatitis
• Lower respiratory tract infections
• Skin and soft tissue infections
• Uncomplicated genital infections due to Chlamydia trachomatis
• Non-gonococcal cervicitis/urethritis due to Chlamydia trachomatis

Dosage:

Uncomplicated gonorrhea

• Adult: 400 mg as a single dose.

Pelvic inflammatory disease

• Adult: 400 mg bid for 14 days.

Urinary tract infections

• Adult: 200-400 mg daily preferably in the morning. If necessary, increase in upper UTI to 400 mg bid.

Prostatitis

• Adult: Acute or chronic: 200 mg bid for 28 days.

Lower respiratory tract infections

• Adult: 400 mg daily preferably in the morning, increased to 400 mg bid as required.

Skin and soft tissue infections

• Adult: 400 mg bid.

Uncomplicated genital infections due to Chlamydia trachomatis; Non-gonococcal cervicitis/urethritis due to Chlamydia trachomatis:

• Adult: 400 mg daily in single or divided doses for 7 days.

Product Details:

Indications:    

• Bacterial vaginosis   
• Anaerobic bacterial infections
• Prophylaxis of postoperative anaerobic bacterial infections   
• Eradication of H. pylori associated with peptic ulcer disease
• Intestinal amoebiasis   
• Hepatic amoebiasis
• Giardiasis   
• Trichomoniasis
• Acute necrotising ulcerative gingivitis   

Dosage:

Bacterial vaginosis

• Adult: 2g as single dose. May also be given as 2g for 2 consecutive days or 1g daily.

 
Anaerobic bacterial infections

• Adult: 2g on the 1st day, followed by 1g daily or 500mg bid for 5-6 days.

Prophylaxis of postoperative anaerobic bacterial infections

• Adult: 2g as single dose 12 hr before surgery.

Eradication of H. pylori associated with peptic ulcer disease

• Adult: 500mg bid, given w/ clarithromycin and omeprazole for 7 days.

Intestinal amoebiasis

• Adult: 2g daily for 2 or 3 days.
• Child: >3 yr 50-60 mg/kg daily for 3 consecutive days. Max: 2g/day.

Hepatic amoebiasis

• Adult: 1.5-2 g daily for 3-6 days.
• Child: >3 yr 50-60 mg/kg daily for 5 days. Max: 2 g/day.

Giardiasis

• Adult: 2 g as single dose.
• Child: >3 yr 50-75 mg/kg as single dose, repeat if necessary. Max: 2 g/day.

Trichomoniasis; Acute necrotising ulcerative gingivitis:

• Adult: 2 g as single dose. In trichomoniasis, partners should be treated at the same time.

Product Details:

Indications:

• Ampicillin + cloxacillin capsules is a beta-lactam antibiotic that has been used extensively to treat bacterial infections. It is effective against gram-negative organisms such as H. influenzae, coliforms, and Proteus SPP. As with other penicillin drugs, ampicillin is relatively non-toxic and adverse effects of a serious nature are rarely encountered.
• Cloxacillin is a semi-synthetic antibiotic in the same class as penicillin used against staphylococci that produce beta-lactamase. It has a weaker antibacterial activity than benzylpenicillin and is devoid of serious toxicity except for allergic reactions.
• Ampicillin + cloxacillin capsules are used to treat respiratory tract infections, ear, nose and throat infections, pelvic infections, urinary tract infections, skin and soft tissue infections, and gastrointestinal infections.

Dosage:

• Adult: Per capsule contains ampicillin 250 mg and cloxacillin 250 mg: 1 capsule 4 times daily. In severe infections, the dose can be increased up to 12 capsules daily.
• Child: Per dose contains ampicillin 125 mg and cloxacillin 125 mg: 1 dose 4 times daily.

Product Details:

Indications:

Cefpodoxime Proxetil 100 Tablets and Cefpodoxime Proxetil 200 Tablets are indicated for use in the short-term treatment of upper and lower respiratory tract infections due to susceptible micro-organisms:

• Acute bronchitis and acute exacerbations of chronic bronchitis
• Pharyngitis and tonsillitis
• Community-acquired bronchopneumonia
• Acute sinusitis.

Dosage:

In Adults

• The dosage of Cefpodoxime Proxetil 100 Tablets and Cefpodoxime Proxetil 200 Tablets depends on the condition being treated and may be increased or decreased accordingly.

Tonsillitis, pharyngitis and acute bronchitis

• One Cefpodoxime Proxetil 100 Tablet every 12 hours with meals (200 mg/day).
• In the treatment of beta-haemolytic streptococcal infections, a therapeutic dose should be administered for at least 10 days.
• Acute sinusitis, acute exacerbations of chronic bronchitis, pneumoniaOne Cefpodoxime Proxetil 200 Tablet or two Cefpodoxime Proxetil 100 Tablets every 12 hours with meals (400 mg/day).

Elderly patients

• Where renal function is normal, it is not necessary to adjust the dose.

Renal Insufficiency

• For values below 40 mL/min, the daily dosage regimen should be reduced by half and administered as a single daily dose for values 10-39 mL/min, every second day for values below 10 mL/min, and after each dialysis session for haemodialysis patients.

In Children:

• The constituted product contains cefpodoxime 8 mg/mL.
• An average dose of 8 mg/kg/day may be administered in two equally divided doses at 12 hourly intervals without regard to food.

Product Details:

Indications:              

• Ear infections (otitis media),
• Nose (acute sinusitis),
• Throat(pharyngoamygdalitis) and lung (pneumonia).
• Urinary tract infections (cystitis, pyelonephritis, and gonococcal urethritis).
• Skin and subcutaneous tissue infections.

Dosage:

• Adults: Usual dose is 250 mg every 8 hours. For infections more severe or caused by less susceptible organisms, doses may be doubled (500 mg) every 8 hours. Total daily dose should not exceed 4 g.
• For treatment of acute gonococcal urethritis in men and women, it is recommended a single dose of 3 g of cefaclor with 1 g probenecid.
• Children:
• The usual recommended dose is 20 mg/kg/day, divided into 3 doses a day.
• In more severe infections, otitis media, sinusitis and infections caused by less susceptible organisms, 40 mg/kg/day is recommended, divided into 3 doses a day. Total daily dose should not exceed 1 gram.

Product Details:

Indications:

• Upper Respiratory Tract Infections (URTI): e.g. otitis media; and other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics, or where treatment failure may carry significant risk.
• Lower Respiratory Tract Infection: e.g. bronchitis.
• Urinary Tract Infections: e.g. cystitis, cystourethritis, uncomplicated pyelonephritis.
• Clinical efficacy has been demonstrated in infections caused by commonly occuring pathogens including Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Kliebsiella species, Haemophilus influenzae (beta-lactamase positive and negative), Branhamella catarrhalis (beta-lactamase positive and negative) and Enterobacter species. Cefixime is highly stable in the presence of beta-lactamase enzymes.
• Most strains of enterococci (Streptococcus faecalis, group D Streptococci) and Staphylococci (including coagulase positive and negative strains and meticillin-resistant strains) are resistant to Cefixime. In addition, most strains of Pseudomonas, Bacteriodes fragalis, Listeria monocytogenes and Clostridia are resistant to Cefixime.

Dosage:

• Adults and Children over 10 Years: The recommended adult dosage is 200-400 mg daily according to the severity of infection, given either as a single dose or in two divided doses.
• The Elderly: Elderly patients may be given the same dose as recommended for adults. Renal function should be assessed and dosage should be adjusted in severe renal impairment (See “Dosage in Renal Impairment”).
• Children (Use Paediatric Oral Suspension): The recommended dosage for children is 8 mg/kg/day administered as a single dose or in two divided doses.
• Children weighing more than 50 kg or older than 10 years should be treated with the recommended adult dose (200 - 400 mg daily depending on the severity of infection).
• The safety and efficacy of cefixime has not been established in children less than 6 months.

As a general guide for prescribing in children the following daily doses in terms of volume of Paediatric Oral Suspension are suggested:

Product Details:

Indications:

• Acute bacterial exacerbations of chronic bronchitis
• Acute community acquired Pneumonia
• Upper and lower respiratory tract infections
• Skin and soft tissue infections
• Urinary tract infections
• Pharyngitis and/or tonsillitis
• General gonorrhea (men and women) and rectal gonococcal infections (women)
• Acute maxillary sinusitis

Dosage:
 

Product Details:

Indications:

Cefpodoxime Proxetil 100 Tablets and Cefpodoxime Proxetil 200 Tablets are indicated for use in the short-term treatment of upper and lower respiratory tract infections due to susceptible micro-organisms:

• Acute bronchitis and acute exacerbations of chronic bronchitis
• Pharyngitis and tonsillitis
• Community-acquired bronchopneumonia
• Acute sinusitis.

Dosage:

In Adults

• The dosage of Cefpodoxime Proxetil 100 Tablets and Cefpodoxime Proxetil 200 Tablets depends on the condition being treated and may be increased or decreased accordingly.

Tonsillitis, pharyngitis and acute bronchitis

• One Cefpodoxime Proxetil 100 Tablet every 12 hours with meals (200 mg/day).
• In the treatment of beta-haemolytic streptococcal infections, a therapeutic dose should be administered for at least 10 days.

Acute sinusitis, acute exacerbations of chronic bronchitis, pneumonia

• One Cefpodoxime Proxetil 200 Tablet or two Cefpodoxime Proxetil 100 Tablets every 12 hours with meals (400 mg/day).

Elderly patients

• Where renal function is normal, it is not necessary to adjust the dose.

Renal Insufficiency

• For values below 40 mL/min, the daily dosage regimen should be reduced by half and administered as a single daily dose for values 10-39 mL/min, every second day for values below 10 mL/min, and after each dialysis session for haemodialysis patients.

In Children:

• The constituted product contains cefpodoxime 8 mg/mL.
• An average dose of 8 mg/kg/day may be administered in two equally divided doses at 12 hourly intervals without regard to food.

Product Details:

Indications:              

• FLOXIM-CV 325 is indicated for the treatment of:
• Uncomplicated Urinary Tract Infections caused by Escherichia coli and Proteus mirabilis.
• Otitis Media: caused by Haemophilusinfluenzae (beta-lactamase positive and negative strains), Moraxella (Branhamella) catarrhalis, (most of which are beta-lactamase positive) and S. pyogenes.
• Pharyngitis and Tonsillitis: caused by S. pyogenes.
• Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis: caused by Streptococcus pneumoniae and Haemophilusinfluenzae (beta-lactamase positive and negative strains).
• Uncomplicated gonorrhea (cervical/urethral): caused by Neisseria gonorrhoeae (penicillinase-and non-penicillinase- producing strains).

Dosage:

• Adults and Children over 10 Years: One tablet twice daily. The usual course of treatment is 7 days. This may be continued for up to 14 days if required.

Product Details:

Indications:

• Urinary tract infections
• Upper and Lower respiratory tract infections
• Acute otitis media.
• Gonococcal urethritis
• Typhoid.

Dosage:

• It can be given to the adults in the following dosages. The usual adult of Cefixime (anhydrous) is 200 – 400 mg per day administered orally, either as a single dose or in two divided doses, although lower doses may prove sufficient to treat uncomplicated urinary tract infections.
• For Children: 8 mg/kg daily, as either a single dose or in two divided doses, is recommended. In uncomplicated gonococcal urethritis, a single oral dose of 400 mg has been found to be effective.

Product Details:

Indications:

• Respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections
• Acute otitis media
• Uncomplicated gonorrhoea

Dosage:

Oral
1.Urinary tract infections:

• Adult: 100-200 mg every 12 hours.
• Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg daily.
• Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
• CrCl (ml/min) Dosage Recommendation
• 10-39 Increase dosing intervals to 24 hourly.
• <10 Increase dosing intervals to 48 hourly.

Oral

2.Respiratory tract infections:

• Adult: 100-200 mg every 12 hours.
• Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg daily.Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
• CrCl (ml/min) Dosage Recommendation
• 10-39 Increase dosing intervals to 24 hourly.
• <10 Increase dosing intervals to 48 hourly.

Oral
3.Skin infections:

• Adult: 200-400 mg every 12 hours.
• Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg/day.
• Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
• CrCl (ml/min) Dosage Recommendation
• 10-39 Increase dosing intervals to 24 hourly.
• <10 Increase dosing intervals to 48 hourly.

Oral
4.Otitis media:

• Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg daily.
• Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
• CrCl (ml/min) Dosage Recommendation
• 10-39 Increase dosing intervals to 24 hourly.
• <10 Increase dosing intervals to 48 hourly.

Oral

5.Uncomplicated gonorrhea:

• Adult: A single dose of 200 mg may be used.
• Renal impairment: Dose reduction may be required.

Product Details:

Indications:

• Respiratory tract infections, including pneumonia, bronchitis, exacerbations of chronic bronchitis, pharyngitis and tonsillitis, and as part of the management of sinusitis
• Otitis media
• Skin and soft tissue infections
• Urinary tract infections, including pyelonephritis and cystitis
• Cefaclor has been found to be effective in both acute and chronic urinary tract infections.
• Cefaclor is generally effective in the eradication of streptococci from the nasopharynx, however, data establishing efficacy in the subsequent prevention of either rheumatic fever or bacterial endocarditis are not available.

Dosage:

• Adults: The usual adult dosage is 250mg every eight hours. For more severe infections or those caused by less susceptible organisms, doses may be doubled. Doses of 4g per day have been administered safely to normal subjects for 28 days, but the total daily dosage should not exceed this amount.
• Cefaclor may be administered in the presence of impaired renal function. Under such conditions dosage is usually unchanged (see 'Special Warning and Special Precautions for Use').
• Patients undergoing haemodialysis: Haemodialysis shortens serum half-life by 25-30%. In patients undergoing regular haemodialysis, a loading dose of 250mg-1g administered prior to dialysis and a therapeutic dose of 250-500mg every six to eight hours maintained during interdialytic periods is recommended.
• The elderly: As for adults.

 
Paediatric population:

• The usual recommended daily dosage for children is 20mg/kg/day in divided doses every eight hours, as indicated. For bronchitis and pneumonia, the dosage is 20mg/kg/day in divided doses administered 3 times daily. For otitis media and pharyngitis, the total daily dosage may be divided and administered every 12 hours. Safety and efficacy have not been established for use in infants aged less than one month.

Product Details:

Indications:

• Skin and soft tissue infections
• Uncomplicated urinary tract infections
• Bone and joint infections
• Respiratory tract infections
• Streptococcal pharyngitis
• Otitis media

Dosage:

Skin and soft tissue infections:

• Adult: 500 mg 12 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Uncomplicated urinary tract infections:

• Adult: 500 mg 12 hrly for 7-14 days. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Bone and joint infections:

• Adult: 250 mg 6 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Respiratory tract infections:

• Adult: 250 mg 6 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Streptococcal pharyngitis:

• Adult: 500 mg 12 hrly for at least 10 days. Max: 4 g/day in divided doses.
• Child: >1 yr 25-50 mg/kg/day in divided doses 12 hrly for at least 10 days.

Otitis media:

• Child: 75-100 mg/kg/day in 4 divided doses.

Product Details:

Indications:

• Biliary tract infections
• Endocarditis; Otitis media
• Peritonitis; Bronchitis
• Perinatal streptococcal infections
• Gastroenteritis; Listeriosis
• Typhoid and paratyphoid fever
• Uncomplicated gonorrhoea
• Urinary tract infections

Dosage:

Biliary tract infections; Endocarditis; Otitis media; Peritonitis; Bronchitis; Perinatal streptococcal infections; Gastroenteritis; Listeriosis:

• Adult: 0.25-1 g 6 hrly.
• Child: <10 yr Half of adult routine dosage.

Typhoid and paratyphoid fever:

• Adult: 1-2 g 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers.

Uncomplicated gonorrhoea:

• Adult: 2 g w/ 1 g of probenecid as single dose, recommended to be repeated in female patients.

Urinary tract infections:

• Adult: 500 mg 8 hrly.

Product Details:

Indications:               

• Skin and soft tissue infections
• Uncomplicated urinary tract infections
• Bone and joint infections
• Respiratory tract infections
• Streptococcal pharyngitis
• Otitis media

Dosage:

Skin and soft tissue infections:

• Adult: 500 mg 12 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Uncomplicated urinary tract infections:

• Adult: 500 mg 12 hrly for 7-14 days. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Bone and joint infections:

• Adult: 250 mg 6 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Respiratory tract infections:

• Adult: 250 mg 6 hrly. Max: 4 g daily in divided doses.
• Child: 25-50 mg/kg/day in divided doses 12 hrly.

Streptococcal pharyngitis:

• Adult: 500 mg 12 hrly for at least 10 days. Max: 4 g/day in divided doses.
• Child: >1 yr 25-50 mg/kg/day in divided doses 12 hrly for at least 10 days.

Otitis media:

• Child: 75-100 mg/kg/day in 4 divided doses.

Product Details:

Indications: 

• Gynaecological infections
• Intra-abdominal infections
• Respiratory tract infections
• Prophylaxis of surgical infections

Dosage:

• Adult: As tablet containing ciprofloxacin (mg)/tinidazole (mg): 500/600, 250/300. Usually 1 tablet bid for 5-10 days depending on severity and response.

Product Details:

Indications:    

• Acute bacterial sinusitis
• Acute bacterial exacerbation of chronic bronchitis
• Community-acquired pneumonia
• Complicated skin and skin structure infections
• Uncomplicated urinary tract infections
• Complicated urinary tract infections
• Pyelonephritis
• Chronic bacterial prostatitis
• Treatment and postexposure prophylaxis of inhalation anthrax

Dosage:
Cute bacterial sinusitis:
Adult: 500 mg once daily for 10-14 days.

Acute bacterial exacerbation of chronic bronchitis; Pyelonephritis:
Adult: 500 mg once daily for 7-10 days.

Community-acquired pneumonia; Complicated skin and skin structure
infections; Complicated urinary tract infections:
Adult: 500 mg once daily or bid for 7-14 days.

Uncomplicated urinary tract infections:
Adult: 250 mg once daily for 3 days.

Chronic bacterial prostatitis:
Adult: 500 mg once daily for 28 days.

Treatment and postexposure prophylaxis of inhalation anthrax:
Adult: 500 mg once daily for 8 wk.
Child: ≥6 mth ≤50 kg: 8 mg/kg 12 hrly for 60 days (not to exceed 250 mg/dose).
 >50 kg: 500 mg 24 hrly for 60 days.

Product Details:

Indications:    

• Acute bacterial sinusitis
• Acute bacterial exacerbation of chronic bronchitis
• Community-acquired pneumonia
• Complicated skin and skin structure infections
• Uncomplicated urinary tract infections
• Complicated urinary tract infections
• Pyelonephritis
• Chronic bacterial prostatitis
• Treatment and postexposure prophylaxis of inhalation anthrax

Dosage:
cute bacterial sinusitis:
Adult: 500 mg once daily for 10-14 days.
Acute bacterial exacerbation of chronic bronchitis; Pyelonephritis:
Adult: 500 mg once daily for 7-10 days.
Community-acquired pneumonia; Complicated skin and skin structure
infections; Complicated urinary tract infections:
Adult: 500 mg once daily or bid for 7-14 days.
Uncomplicated urinary tract infections:
Adult: 250 mg once daily for 3 days.
Chronic bacterial prostatitis:
Adult: 500 mg once daily for 28 days.
Treatment and postexposure prophylaxis of inhalation anthrax:
Adult: 500 mg once daily for 8 wk.
Child: ≥6 mth ≤50 kg: 8 mg/kg 12 hrly for 60 days (not to exceed 250 mg/dose).
>50 kg: 500 mg 24 hrly for 60 days.

Product Details:

Azithromycin is used to treat a wide variety of bacterial infections. It is a macrolide-type antibiotic. It works by stopping the growth of bacteria. This medication will not work for viral infections (such as common cold, flu)