Antifungals

Product Details:

• Topically for oral, vaginal and cutaneous candidiasis and otomycosis. Most effective for various types of systemic mycoses. Intravenously for treatment of progressive and potential fatal fungal infections. Intestinal moniliasis.

• Orally-50-100mg four times.For Systemic mycoses, Initially 1 mg test dose is injected over 20 mins i.v. followed by 0.3 mg/kg body wt is infused over 4-8hrs. Max of 0.7 mg/kg body wt

Product Details:

• Treatment of Cryptococcal Meningitis in HIV infected patients.
• Treatment of patients with Aspergillus species, Candida species and/or Cryptococcus species infections refractory to amphotericin B deoxycholate.
• In patients where renal impairment or unacceptable toxicity precludes the use of amphotericin B deoxycholate.
• Treatment of visceral leishmaniasis, in immuno-compromised/ immunocompetent patients.
• Empirical therapy in febrile immunocompromised patients who do not respond to broad-spectrum antibiotics.

• For systemic mycoses
• For prophylaxis against invasive fungal infections in liver transplant recipients
• In HIV-associated disseminated cryptococcosis
• Visceral leishmaniasis (immunocompromised patients)
• For empirical treatment of presumed fungal infection of febrile neutropaenic patients
• 1mg/kg/day of body weight, and increased stepwise to 5.0mg/kg/day, as required.
• 1mg/kg/day for five successive days following transplantation
• 3mg/kg/day for up to 42 days
• 1 to 1.5mg/kg/day for 21 days may be used
• 1-3 mg/kg. The daily dosage may be adjusted based on the clinical condition, as required.

Product Details:

• Systemic mycotic infections due to organisms susceptible to Amphotericin B,where toxicity precludes the use of conventional systemic Amphotericin B therapy. Infections such as disseminated candidiasis, mucormycosis, aspergillosis, cryptococcosis, histoplasmosis have been successfully treated with Liposomal Amphotericin B.
• Fever of unknown origin in neutropenic patients where the fever has failed to respond to broad spectrum antibiotic therapy and appropriate investigations carried out have failed to establish the cause as bacterial or viral.
• Visceral leishmaniasis in both adults and children.

• Adults: Not necessary with renal impairment if decreased renal function is due to amphotericin B the daily dose can be adjusted.
• Children: 5mg/kg given as a single IV infusion daily.

• Renal Impairment: Not necessary with renal impairment if the decreased renal function is due to amphotericin B the daily dose can be adjusted.
• Hepatic Impairment: Administer with caution.

Product Details:

• Oropharyngeal Candidiasis: used to treat fungal infection in the mouth.
• Esophageal Candidiasis: used to treat fungal infection in throat and neck.
• Cryptococcal Meningitis: used to treat meningitis caused by a group of fungi of Cryptococcus strain.
• Vaginal Candidiasis: used to treat yeast infection in the female genital organ.
• Urinary Tract Infection: used to treat fungal infections of the urinary tract.
• Peritonitis: used to treat fungal infection in the abdomen.
• Candidemia: used to treat fungal infection of the male genital organ.
• Prophylaxis of Infections in Special Population: used for preventing possible fungal infections in people who are undergoing chemotherapy or have AIDS.

• Vaginal candidiasis: in adults is 150 mg as a one-time dose.
• Oropharyngeal candidiasis:?? in adults is 200 mg on the first day, followed by 100 mg once daily.
• Esophageal candidiasis: in adults is 200 mg on the first day, followed by 100 mg to 400 mg once daily.
• The recommended dose of fluconazole for the treatment of systemic candida infections in adults is up to 400 mg once daily.
• UTIs and peritonitis:?? in adults is 50 mg to 200 mg once daily.
• Cryptococcal meningitis:?? in adults is 400 mg on the first day, followed by 200 mg to 400 mg once daily.
• The recommended dose of fluconazole to prevent infection in adults undergoing bone marrow transplant is 400 mg once daily.
• Oropharyngeal candidiasis: in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily.
• Esophageal candidiasis: in children is 6 mg/kg on the first day, followed by 3 mg/kg to 12 mg/kg once daily.
• Candida infections: in children is 6-12 mg/kg once daily.
• Cryptococcal meningitis: in children is 12 mg/kg on the first day, followed by 6 mg/kg to 12 mg/kg once daily.

Product Details:

• Candidiasis (thrush) of the mucus membranes such as in the mouth and also of the skin.
• Systemic candidiasis, like candidaemia, which is can be more serious particularly if the immune system is compromised as in AIDS, transplant or cancer patients.
• Tinea (ringworm) of the body (tinea pedis), foot (tinea corporis) and groin (tinea cruris or jock itch).
• Cryptococcal meningitis.
• Fluconazole tablets 50mg/100mg are also used to prevent fungal infections like cryptococcal disease in immunocompromised patients and to prevent recurrent vaginal candidiasis.

• You should take your Fluconazole tablets with a glass of water with or without food usually once a day for several days or months, depending on what you are being treated for, the severity of your infection and your doctor's recommendations.  You should continue to take your Fluconazole 50 tablets for as long as recommended by your doctor and always finish your course of tablets even if you feel better, if not, the infection may not clear up completely.

Product Details:

• Itraconazole capsules are indicated for the treatment of-
• Vulvovaginal candidiasis
• Pityriasis Versicolor, dermatomycosis, fungal keratitis, oral candidiasis
• Onychomycosis caused by dermatophytes and/or yeasts
• Systemic mycoses, including aspergillosis and non-invasive systemic candidiasis(without underlying Immunosuppression), histoplasmosis, sporotrichosis, paracoccidioidomycosis, blastomycosis, and other rarely occurring systemic or tropical mycoses

• The number of capsules and the duration of treatment will depend on the fungus and on the location of the infection.
• Vaginal infections 2 capsules (200mg itraconazole) twice a day for 1 day or 2 capsules (200mg itraconazole) once a day for 3 days.
• Skin infections 2 capsules (200mg itraconazole) once a day 7 days or 1 capsule (100mg itraconazole) once a day 15 days.
• If there is a thin layer of callus on the palms of the hands or soles of the feet, it may be necessary to take 2 capsules (200mg itraconazole) twice a day for 7 days or 1 capsule (100mg itraconazole) once a day for one month.
• Infections of the mouth 1 capsule (100mg itraconazole) once a day for 15 days.
• Infections of the internal organs Higher doses Longer periods.
• Continuous nail treatment 2 capsules (200mg itraconazole) once a day for 3 months.

Product Details:

• Susceptible systemic fungal infections (blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, paracoccidioidomycosis) in those who have failed or are intolerant to other therapies. Do not use for fungal meningitis.

• Adult Initially 200mg daily; max 400mg daily. Usual duration 6 months.

Product Details:

• Presumed fungal infections in febrile neutropenia, as empiric therapy. Candida infections of the esophagus, blood, peritoneum, intraabdominal abscess, pleural space. Invasive aspergillosis in patients refractory to or intolerant of other therapies (not for initial therapy).

• Give by slow IV infusion over 1hr. ???18yrs: Esophageal candidiasis: 50mg once daily. Other Candida infections, aspergillosis, or empiric: 70mg once on Day 1 then 50mg daily. Empiric: treat for at least 14 days; continue for at least 7 more days after resolution of neutropenia and clinical symptoms; may increase to 70mg/day. All others: continue at least 14 days after last positive culture. Moderate hepatic impairment: 35mg daily (may give 70mg on Day 1 when indicated). Concomitant rifampin: 70mg once daily. Concomitant other CYP inducers (eg, nevirapine, efavirenz, carbamazepine, dexamethasone, phenytoin): consider 70mg once daily.

• <3months: not established. Give by slow IV infusion over 1hr. 3mos-17yrs: 70mg/m2 once on Day 1, then 50mg/m2 daily. May increase to 70mg/m2 daily; max 70mg. Empiric: treat for at least 14 days; continue for at least 7 more days after resolution of neutropenia and clinical symptoms. All others: continue at least 14 days after last positive culture. Concomitant rifampin: 70mg/m2 once daily. Concomitant other CYP inducers (eg, nevirapine, efavirenz, carbamazepine, dexamethasone, phenytoin): consider 70mg/m2 once daily.

Product Details:

• Treatment of invasive aspergillosis.
• Treatment of candidaemia in non-neutropenic patients.
• Treatment of fluconazole-resistant serious invasive Candida infections (including C. krusei).
• Treatment of serious fungal infections caused by Scedosporium spp. and Fusarium\ spp.
• Voriconazole I.V. should be administered primarily to patients with progressive, possibly life-threatening infections

• Adult & adolescent Loading dose (1st 24 hr) 6 mg/kg IV 12 hrly.
• Patient ???40 kg Prophylaxis of invasive fungal infections &/or breakthrough infections Maintenance dose (after 1st 24 hr) 3-4 mg/kg IV or 200 mg PO 12 hrly.
• Invasive aspergillosis/Scedosporium & Fusarium infections/serious mould infections or other serious fungal infections resistant to other therapy 4 mg/kg IV or 200 mg PO 12 hrly.
• Candidemia in non-neutropenic patient 3-4 mg/kg IV or 200 mg PO 12 hrly.
• Esophageal candidiasis 200 mg PO 12 hrly. Max rate 3 mg/kg/hr over 1-3 hr. Patient <40 kg 100 mg PO 12 hrly.

Product Details:

• Fluconazole tablet 150mg is indicated for the treatment of candidal vaginitis, acute or recurrent. It should also be used for treatment of partners with associated candidal balanitis.

• Fluconazole is administered orally.

• One capsule should be swallowed whole.

• Paediatric use is not recommended.

• Not recommended in patients over 60 years.

• There is no separate dosage schedule in patients with renal impairment for single dose therapy.

Product Details:

• Treatment of invasive aspergillosis.
• Treatment of candidaemia in non-neutropenic patients.
• Treatment of fluconazole-resistant serious invasive Candida infections (including C. krusei).
• Treatment of serious fungal infections caused by Scedosporium spp. and Fusarium\ spp.
• Voriconazole-200 Tablets should be administered primarily to patients with progressive, possibly life-threatening infections

• Adult PO- The recommended dose for patients with greater than 40 kg body weight is 400 mg 12 hourly for the 1st 24 hours. Maintenance 200 mg 12 hourly, upto 300 mg 12 hourly if needed.
• The recommended dose for patients with less than 40 kg body weight is 200 mg 12 hourly for the 1st 24 hours. Maintenance 100 mg 12 hourly, upto 150 mg 12 hourly if needed.
• IV- Loading dose 6 mg/kg 12 hourly for the 1st 24 hours. Maintenance 4 mg/kg 12 hourly.