Florencia Healthcare
Florencia Healthcare
Delhi
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Antituberculosis

Our range of products include cycloserine tablets 250mg and prothionamide tablets 250mg.

Cycloserine Tablets 250mg

Cycloserine Tablets 250mg
  • Cycloserine Tablets 250mg
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Product Details:

Packaging Size1 strip of 10 tablets
Packaging TypeBox
Brandn/a
UsageClinical, Hospital, Personal
Dose Or Strength (Mg)250mg
CompositionCycloserine Tablets

Indication:
  • Cycloserine is indicated in the treatment of active pulmonary and extra-pulmonary tuberculosis (including renal disease) when the organisms are susceptible to this drug and after failure of adequate treatment with the primary medications (streptomycin, isoniazid, rifampicin and ethambutol).
  • Like all anti-tuberculous drugs, cycloserine should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent.
  • Cycloserine may be effective in the treatment of acute urinary tract infections caused by susceptible strains of Gram-positive and Gram-negative bacteria, especially Klebsiella/Enterobacter species and Escherichia coli.
  • It is generally no more and may be less effective than other antimicrobial agents in the treatment of urinary tract infections caused by bacteria other than mycobacteria.
  • Use of cycloserine in these infections should be considered only when the more conventional therapy has failed and when the organism has been demonstrated to be sensitive to the drug.

Dosage:
  • Adults: the usual dosage is 500 mg to 1 g daily in divided doses, monitored by blood level determinations. The initial adult dosage most frequently given is 250 mg twice daily at 12-hour intervals for the first two weeks. A daily dosage of 1g should not be exceeded.
  • The elderly: as for adults but reduce dosage if renal function is impaired.
  • Paediatric population
  • The usual starting dose is 10 mg/ kg/ day, then adjusted according to blood levels obtained and therapeutic response.
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Prothionamide Tablets 250mg

Prothionamide Tablets 250mg
  • Prothionamide Tablets 250mg
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Product Details:

Dose250 mg
UsageClinical, Hospital, Personal
Packaging Size1x10 tablets
Packaging TypeBox
Brandn/a
CompositionProthionamide Tablets

Indications
  • Prothionamide is primarily indicated for the treatment of active tuberculosis in patients with M. tuberculosisresistant to isoniazid or rifampin, or when there is intolerance on the part of the patient to other drugs. Its use alone in the treatment of tuberculosis results in the rapid development of resistance.
  • ??It is essential, therefore, to give a suitable companion drug or drugs, the choice being based on the results of susceptibility tests.
  • If the susceptibility tests indicate that the patient's organism is resistant to one of the first-line antituberculosis drugs (i.e., isoniazid or rifampin) yet susceptible to ethionamide, ethionamide should be accompanied by at least one drug to which the M. tuberculosis isolate is known to be susceptible.
  • If the tuberculosis is resistant to both isoniazid and rifampin, yet susceptible to ethionamide, ethionamide should be accompanied by at least two other drugs to which the M. tuberculosis isolate is known to be susceptible.

Dosage
  • Adult & paediatric doses are the same per kg.
  • Adults 15-20mg/kg (max. 1g) once daily (oral).
  • Once daily dosing is preferred to maximise peak levels, particularly for daily doses ???750mg. Consider twice daily dosing if patients are unable to tolerate once daily regimens.
  • Children 15-20mg/kg (max. 1g) once daily (oral).
  • Once daily dosing is preferred to maximise peak levels, particularly for daily doses ???750mg. Consider twice daily dosing if patients are unable to tolerate once daily regimens.
  • WHO advise a once daily dosing regimen if tolerated (to maximise peak levels), but twice daily regimens may be required if unable to tolerate.
  • Prothionamide should be taken with or after meals to reduce gastrointestinal adverse effects.?? Most patients also require gradual dose escalation, i.e. for adults initially 250mg once a day, increasing by 250mg every 3 to 5 days.
  • All patients must be prescribed pyridoxine whilst receiving prothionamide.?? The usual adult dose ranges from 50 to 100mg daily, up to 50mg per 250mg of prothionamide.
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Reshma Mishra (CEO)
Florencia Healthcare
5/71, Rajeev Gali, Dayal Pur
Delhi - 110094, India


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