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Antituberculosis

Our range of products include aminosalicylate sodium tablets 500 mg, cycloserine tablets 250mg, ethambutol tablets 400mg, isoniazid tablets 300mg, prothionamide tablets 250mg and pyrazinamide tablets 500mg.

Aminosalicylate Sodium Tablets 500 mg

Aminosalicylate Sodium Tablets 500 mg
  • Aminosalicylate Sodium Tablets 500 mg
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Product Details:

Packaging TypeBox
BrandFLOAS-TB
Packing Size1 strip of 10 tablets
Dose500mg
UsageClinical, Hospital, Personal
CompositionAminosalicylate Sodium Tablets

Indications:
  • Indicated for the treatment of tuberculosis in combination with other active agents. It is most commonly used in patients with Multi-drug Resistant TB (MDR-TB) or in situations when therapy with isoniazid and rifampin is not possible due to a combination of resistance and/or intolerance.
  • When tablet added to the treatment regimen in patients proven or suspected drug resistance, it should be accompanied by at least one and preferably two other new agents to which the patient's organism is known or expected to be susceptible.

Dosage:
  • Adults and Children
  • PO 150 mg/kg (max, 12 g/day).
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Cycloserine Tablets 250mg

Cycloserine Tablets 250mg
  • Cycloserine Tablets 250mg
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Product Details:

Packaging TypeBox
UsageClinical, Hospital, Personal
BrandClotab-TB
Packaging Size1 strip of 10 tablets
Dose Or Strength (Mg)250mg
CompositionCycloserine Tablets

Indication:
  • Cycloserine is indicated in the treatment of active pulmonary and extra-pulmonary tuberculosis (including renal disease) when the organisms are susceptible to this drug and after failure of adequate treatment with the primary medications (streptomycin, isoniazid, rifampicin and ethambutol).
  • Like all anti-tuberculous drugs, cycloserine should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent.
  • Cycloserine may be effective in the treatment of acute urinary tract infections caused by susceptible strains of Gram-positive and Gram-negative bacteria, especially Klebsiella/Enterobacter species and Escherichia coli.
  • It is generally no more and may be less effective than other antimicrobial agents in the treatment of urinary tract infections caused by bacteria other than mycobacteria.
  • Use of cycloserine in these infections should be considered only when the more conventional therapy has failed and when the organism has been demonstrated to be sensitive to the drug.

Dosage:
  • Adults: the usual dosage is 500 mg to 1 g daily in divided doses, monitored by blood level determinations. The initial adult dosage most frequently given is 250 mg twice daily at 12-hour intervals for the first two weeks. A daily dosage of 1g should not be exceeded.
  • The elderly: as for adults but reduce dosage if renal function is impaired.
  • Paediatric population
  • The usual starting dose is 10 mg/ kg/ day, then adjusted according to blood levels obtained and therapeutic response.
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Ethambutol Tablets 400mg

Ethambutol Tablets 400mg
  • Ethambutol Tablets 400mg
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Product Details:

Packaging TypeBox
BrandEtham-TB
Packing Size1x10 tablets
Strength (mg)400
UsageClinical, Hospital, Personal
CompositionEthambutol Tablets

Indications:
  • The primary treatment and re-treatment of tuberculosis and for prophylaxis in cases of inactive tuberculosis or large-tuberculin-positive reaction.
  • Ethambutol should only be used in conjunction with other anti-tuberculous drugs to which the patients organisms are susceptible.¿¿¿¿¿¿¿¿¿¿¿¿¿¿

Dosage:
  • The dosage of Ethambutol must be adjusted according to the body weight of the patient.

Adults:
  • For primary treatment and prophylaxis: Ethambutol should be administered in a single daily oral dose of 15mg/kg, concomitant drugs being maintained at their recommended dosage levels.
  • For re-treatment: For the first 60 days of treatment, Ethambutol should be administered in a single daily oral dose of 25mg/kg. Thereafter the dosage should be reduced to 15mg/kg, concomitant drugs being maintained at their recommended dosage levels.

Children:
  • For primary treatment and re-treatment: For the first 60 days of treatment, a single daily oral dose of 25mg/kg. Thereafter the dosage should be reduced to 15mg/kg, concomitant drugs being maintained at their recommended dosage levels.
  • For prophylaxis: A single daily oral dose of 15mg/kg, concomitant drugs being used at their recommended dosage levels.

Elderly:
  • As for adults: However, patients with decreased renal function may need to have the dosage adjusted as determined by blood levels of Ethambutol.
  • In order to obtain maximum effect due to high serum levels, drug administration should be once daily.

Renal Impairment:
  • Renal function should be checked before treatment with antituberculous drugs and appropriate dosage adjustments made. Ethambutol should preferably be avoided in patients with renal impairment
  • If used, where creatinine clearance is less than 30mL/minute, use 15-25 mg/kg (max. 2.5 g) 3 times a week and plasma ethambutol concentration should be monitored.
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Isoniazid Tablets 300mg

Isoniazid Tablets 300mg
  • Isoniazid Tablets 300mg
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Product Details:

Packaging Size1x10 tablets
Dose Or Strength (Mg)300 mg
UsageClinical, Hospital, Personal
BrandFloniazid
Packaging TypeBox
CompositionIsoniazid Tablets

Indications:
  • For all forms of pulmonary and extra-pulmonary tuberculosis.

Dosage:
  • For Treatment of Tuberculosis
  • Isoniazid is used in conjunction with other effective anti-tuberculous agents. Drug susceptibility testing should be performed on the organisms initially isolated from all patients with newly diagnosed tuberculosis. If the bacilli becomes resistant, therapy must be changed to agents to which the bacilli are susceptible.
  • Usual Oral Dosage (depending on the regimen used):

Adults
  • 5 mg/kg up to 300 mg daily in a single dose; or
  • 15 mg/kg up to 900 mg/day, two or three times/week

Children
  • 10 mg/kg to 15 mg/kg up to 300 mg daily in a single dose; or
  • 20 mg/kg to 40 mg/kg up to 900 mg/day, two or three times/week

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Prothionamide Tablets 250mg

Prothionamide Tablets 250mg
  • Prothionamide Tablets 250mg
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Product Details:

Packaging Size1x10 tablets
Dose250 mg
Packaging TypeBox
UsageClinical, Hospital, Personal
BrandPramide
CompositionProthionamide Tablets

Indications
  • Prothionamide is primarily indicated for the treatment of active tuberculosis in patients with M. tuberculosisresistant to isoniazid or rifampin, or when there is intolerance on the part of the patient to other drugs. Its use alone in the treatment of tuberculosis results in the rapid development of resistance.
  • ¿¿It is essential, therefore, to give a suitable companion drug or drugs, the choice being based on the results of susceptibility tests.
  • If the susceptibility tests indicate that the patient's organism is resistant to one of the first-line antituberculosis drugs (i.e., isoniazid or rifampin) yet susceptible to ethionamide, ethionamide should be accompanied by at least one drug to which the M. tuberculosis isolate is known to be susceptible.
  • If the tuberculosis is resistant to both isoniazid and rifampin, yet susceptible to ethionamide, ethionamide should be accompanied by at least two other drugs to which the M. tuberculosis isolate is known to be susceptible.

Dosage
  • Adult & paediatric doses are the same per kg.
  • Adults 15-20mg/kg (max. 1g) once daily (oral).
  • Once daily dosing is preferred to maximise peak levels, particularly for daily doses ¿¿¿750mg. Consider twice daily dosing if patients are unable to tolerate once daily regimens.
  • Children 15-20mg/kg (max. 1g) once daily (oral).
  • Once daily dosing is preferred to maximise peak levels, particularly for daily doses ¿¿¿750mg. Consider twice daily dosing if patients are unable to tolerate once daily regimens.
  • WHO advise a once daily dosing regimen if tolerated (to maximise peak levels), but twice daily regimens may be required if unable to tolerate.
  • Prothionamide should be taken with or after meals to reduce gastrointestinal adverse effects.¿¿ Most patients also require gradual dose escalation, i.e. for adults initially 250mg once a day, increasing by 250mg every 3 to 5 days.
  • All patients must be prescribed pyridoxine whilst receiving prothionamide.¿¿ The usual adult dose ranges from 50 to 100mg daily, up to 50mg per 250mg of prothionamide.
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Pyrazinamide Tablets 500mg

Pyrazinamide Tablets 500mg
  • Pyrazinamide Tablets 500mg
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Product Details:

Packaging TypeBox
BrandFlotazin
Packing Size1x10 tablets
Strength (mg)500
UsageClinic, Hospital, Personal
CompositionPyrazinamide Tablets

Indications
  • Pyrazinamide' is indicated in patients with active tuberculosis caused by Mycobacterium tuberculosis.
  • Pyrazinamide' is not active against the atypical mycobacteria.
  • Pyrazinamide' should only be given in combination with other antituberculous agents.

Dosage

Recommended dosage for standard unsupervised 2-month treatment
  • Adults Under 50kg bodyweight maximum of 3 tablets or 1.5g daily. 50kg and over bodyweight maximum of 4 tablets or 2g daily.
  • Children 35mg/kg daily.

Recommended dosage for intermittent supervised 2-month treatment
  • Adults Under 50kg bodyweight maximum of 4 tablets or 2g 3 times a week. 50kg and over bodyweight maximum of 5 tablets or 2.5g 3 times a week.
  • Children 50mg/kg 3 times a week.
  • Pyrazinamide' should be administered with at least one other effective antituberculous drug. The use of 'Pyrazinamide' in combination therapy does not modify the accepted dosages of other antituberculous agents.
  • Use in the elderly The general considerations outlined above should also apply to elderly patients.
  • Immunocompromised patients Multi-resistant M. tuberculosis may be present in immunocompromised patients. The organism should always be cultured to confirm its type and drug sensitivity. Confirmed M. Tuberculosis infection sensitive to first-line drugs should be treated with a standard 6 month regimen; after completing treatment, patients should be closely monitored. The regimen may need to be modified if infection is caused by resistant organisms and specialist advice is needed.
  • In meningeal or pericardial tuberculosis, a corticosteroid should be started at the same time as antituberculosis therapy.
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Ethionamide Tablets 250mg/500mg

Ethionamide Tablets 250mg/500mg
  • Ethionamide Tablets 250mg/500mg
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Product Details:

Packing SizeBox
Strength (mg)250, 500
UsageClinic, Hospital, Personal
CompositionEthionamide Tablets

Indications:
  • Primarily indicated for the treatment of active tuberculosis in patients with M. tuberculosisresistant to isoniazid or rifampin, or when there is intolerance on the part of the patient to other drugs.
  • Its use alone in the treatment of tuberculosis results in the rapid development of resistance. It is essential, therefore, to give a suitable companion drug or drugs, the choice being based on the results of susceptibility tests.
  • If the susceptibility tests indicate that the patient's organism is resistant to one of the first-line antituberculosis drugs (i.e., isoniazid or rifampin) yet susceptible to ethionamide, ethionamide should be accompanied by at least one drug to which the M. tuberculosis isolate is known to be susceptible. If the tuberculosis is resistant to both isoniazid and rifampin, yet susceptible to ethionamide, ethionamide should be accompanied by at least two other drugs to which the M. tuberculosis isolate is known to be susceptible.

Dosage:

Usual Adult Dose for Tuberculosis - Active:
  • 500 mg to 1 g orally (15 to 20 mg/kg) in 1 or more divided doses per day
  • Maximum dose: 1 g orally per day
  • Duration: Treatment should continue until permanent bacteriological conversion and maximal clinical improvement have occurred, generally, 18 to 24 months.

Usual Pediatric Dose for Tuberculosis - Active:
  • 10 to 20 mg/kg orally in 2 or 3 divided doses per day or 15 mg/kg orally once per day after meals.
  • Maximum dose: 1 g orally per day
  • Duration: Treatment should continue until permanent bacteriological conversion and maximal clinical improvement have occurred, generally, 18 to 24 months.

Renal Dose Adjustments

Adults:
  • CrCl less than 30 mL/min: 250 to 500 mg/day.

Liver Dose Adjustments:
  • Ethionamide is contraindicated in patients with severe hepatic impairment.
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