Gastro Intestinal

Product Details:

Indications

• Erosive Oesophagitis
• Peptic ulcer
• NSAID-associated ulceration
• Zollinger-Ellison syndrome
• Gastro-oesophageal reflux disease
• Prophylaxis of NSAID-induced ulcers

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Dosage

Erosive oesophagitis

• Adult 40 mg once daily for 4 wk, extended for another 4 wk if needed. Maintenance 20 mg once daily.
• Child 1-11 yr 10-20 kg 10 mg; ¿¿¿20 kg 10 or 20 mg. All doses given once daily for 8 wk.

Peptic ulcer

• Adult 20 mg bid for 7 days or 40 mg once daily for 10 days given as a triple therapy w/ amoxicillin and clarithromycin.
• NSAID-associated ulceration
• Adult 20 mg once daily for 4-8 wk.
• Elderly No dosage adjustment needed.

Zollinger-Ellison syndrome

• Adult Initially, 40 mg bid. Usual range 80-160 mg/day. Doses >80 mg should be given in 2 divided doses.
• Gastro-oesophageal reflux disease
• Adult 40 mg once daily for 4 wk, extended for another 4 wk if needed. Maintenance or GERD w/o erosive oesophagitis 20 mg once daily.
• Child 1-11 yr ¿¿¿10 kg 10 mg once daily for up to 8 wk.
• Prophylaxis of NSAID-induced ulcers
• Adult 20 or 40 mg/day.
• Elderly No dosage adjustment needed.

Product Details:

Indications

• Gastro-oesophageal reflux disease
• NSAID-associated ulceration
• Gastric and duodenal ulcers

Dosage

Gastro-oesophageal reflux disease

• Adult 20 or 40 mg by inj over at least 3 min or infusion over 10-30 min once daily for ¿¿¿10 days. Convert to oral therapy as soon as possible.

NSAID-associated ulceration

• Adult 20 mg/day by inj over at least 3 min or infusion over 10-30 min. Convert to oral therapy as soon as possible.

Gastric and duodenal ulcers

• Adult 80 mg infusion over 30 min followed by continuous infusion of 8 mg/hr over 72 hr, then convert to oral therapy given as 40 mg once daily for 4 wk.
• Elderly No dosage adjustment needed.

Product Details:

Indications¿¿¿¿¿¿

• Peptic ulcer¿¿¿¿¿¿
• Zollinger-Ellison syndrome
• Acid-related dyspepsia¿¿¿¿¿¿
• Gastro-oesophageal reflux disease
• Prophylaxis of NSAID-induced ulcers¿¿¿¿¿¿
• H.pylori infection
• Erosive oesophagitis¿¿¿¿¿¿
• NSAID-associated ulceration

Dosage

Peptic ulcer

• Adult 30 mg once daily in the morning given for up to 4 wk (duodenal ulcer) or for up to 8 wk (gastric ulcer). Maintenance 15 mg/day.

Zollinger-Ellison syndrome

• Adult Initially, 60 mg once daily in the morning and adjust as required. Daily doses >120 mg should be given in 2 divided doses.

Acid-related dyspepsia

• Adult 15-30 mg once daily in the morning for 2-4 wk.

Gastro-oesophageal reflux disease

• Adult 15-30 mg once daily in the morning for 4-8 wk. Maintenance 15-30 mg
• once daily according to response.
• Child 1-11 yr ¿¿¿30 kg 15 mg once daily in the morning for up to 12 wk; >30 kg
• 30 mg once daily in the morning for up to 12 wk. May increase doses up to 30 mg bid if patient is still symptomatic after 2 or more wk of treatment. 12-17 yr 15 mg once daily for up to 8 wk.

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Prophylaxis of NSAID-induced ulcers

• Adult 15-30 mg once daily in the morning.

H.pylori infection

• Adult 1-wk triple therapy 30 mg bid combined w/ clarithromycin 500 mg bid and amoxicillin 1 g bid or combined w/ clarithromycin 250 mg bid and metronidazole 400 mg bid.

Erosive oesophagitis

• Adult 30 mg once daily in the morning for up to 8 wk, additional 8 wk if not healed. Maintenance 15 mg once daily.
• Child 1-11 yr ¿¿¿30 kg 15 mg once daily in the morning for up to 12 wk; >30 kg 30 mg once daily in the morning for up to 12 wk. May increase doses up to 30 mg bid if patient is still symptomatic after 2 or more wk of treatment. 12-17 yr 30 mg once daily for up to 8 wk.

NSAID-associated ulceration

• Adult 30 mg once daily in the morning for 4-8 wk.
• Elderly No dosage adjustment needed.

Product Details:

Indications

• Peptic ulcer
• Zollinger-Ellison syndrome
• Acid-related dyspepsia
• Gastro-oesophageal reflux disease
• Prophylaxis of NSAID-induced ulcers
• H.pylori infection
• Erosive oesophagitis
• NSAID-associated ulceration

Dosage

Peptic ulcer

• Adult 30 mg once daily in the morning given for up to 4 wk (duodenal ulcer) or for up to 8 wk (gastric ulcer). Maintenance 15 mg/day.

Zollinger-Ellison syndrome

• Adult Initially, 60 mg once daily in the morning and adjust as required. Daily doses >120 mg should be given in 2 divided doses.

Acid-related dyspepsia

• Adult 15-30 mg once daily in the morning for 2-4 wk.

Gastro-oesophageal reflux disease

• Adult 15-30 mg once daily in the morning for 4-8 wk. Maintenance 15-30 mg once daily according to response.
• Child 1-11 yr ¿¿¿30 kg 15 mg once daily in the morning for up to 12 wk; >30 kg 30 mg once daily in the morning for up to 12 wk. May increase doses up to 30 mg bid if patient is still symptomatic after 2 or more wk of treatment. 12-17 yr 15 mg once daily for up to 8 wk.

Prophylaxis of NSAID-induced ulcers

• Adult 15-30 mg once daily in the morning.

H.pylori infection

• Adult 1-wk triple therapy 30 mg bid combined w/ clarithromycin 500 mg bid and amoxicillin 1 g bid or combined w/ clarithromycin 250 mg bid and metronidazole 400 mg bid.

Erosive oesophagitis

• Adult 30 mg once daily in the morning for up to 8 wk, additional 8 wk if not healed. Maintenance 15 mg once daily.
• Child 1-11 yr ¿¿¿30 kg 15 mg once daily in the morning for up to 12 wk; >30 kg 30 mg once daily in the morning for up to 12 wk. May increase doses up to 30 mg bid if patient is still symptomatic after 2 or more wk of treatment. 12-17 yr 30 mg once daily for up to 8 wk.

NSAID-associated ulceration

• Adult 30 mg once daily in the morning for 4-8 wk.
• Elderly No dosage adjustment needed.

Product Details:

Indications¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿
Stomach ulcers
Gastroesophageal reflux disease(GERD)
acidity related disorders.

Dosage
For the short-term treatment of frequent dyspepsia or pyrosis (heartburn) that occurs 2 or more times per week.
Oral dosage (capsules, disintegrating tablets¿¿¿, or oral suspension¿¿¿)

Adults
15 mg PO once daily for up to 14 days. Full relief may take 1 to 4 days. Reassess if heartburn returns after 14-day treatment regimen. For non-prescription use (self care) patient should not take for more than 14 days or more often than every 4 months unless directed by a physician.
For the treatment of non-erosive gastroesophageal reflux disease (GERD).
Oral dosage

Adults
15 mg PO once daily 30 to 60 minutes before first meal of the day for up to 8 weeks. Per treatment guidelines, initiate empiric therapy based on a presumptive diagnosis of GERD in the setting of typical symptoms of heartburn and regurgitation. For patients with partial response to once daily therapy, consider lansoprazole 15 mg PO twice daily, 30 to 60 minutes before a meal, or, consider a one-time switch to a different PPI. Refer non-responders for further evaluation. Consider maintenance therapy for patients who continue to have symptoms after PPI discontinuation; the lowest effective dose, including on demand or intermittent therapy should be used with regular assessment of the need for continued PPI therapy. Alternatively, step down maintenance therapy to an H2 blocker is acceptable.

Children and Adolescents 12 years and older
15 mg PO once daily in the morning at least 30 minutes before a meal, for up to 8 weeks.

Children 1 to 11 years weighing 30 kg or more
30 mg PO once daily in the morning at least 30 minutes before a meal, for up to 12 weeks. Initial doses of 1.4 to 1.5 mg/kg/day PO have been reported in medical literature. The dosage was increased (Max 30 mg PO twice daily) in some children who were symptomatic after 2 weeks in trials ; however, the usual maximum adult dosage for most indications is 30 mg/day.

Children 1 to 11 years weighing less than 30 kg
15 mg PO once daily in the morning at least 30 minutes before a meal, for up to 12 weeks. Alternatively, a dose range of 0.7 to 3 mg/kg/day PO is recommended by the American Academy of Pediatrics (AAP). Initial doses of 1.4 to 1.5 mg/kg/day PO have also been suggested in medical literature.

Product Details:

<b>Indications              </b> <br /> <ul><li>Heartburn </li><li>Sour stomach</li><li>Acid indigestion</li><li>Bloating, pressure and discomfort commonly referred to as gas</li></ul><br /><b>Dosage</b> <br /> <ul><li>For adults and children 12 years of age and older Chew 2 to 4 tablets.  Repeat hourly if symptoms return, or as directed by a physician Do not take more than 12 tablets in a 24-hour period, or use the maximum dosage for more than 2 weeks, except under the advice and supervision of a physician Children under 12 ask a doctor</li></ul>

Product Details:

<b>Indications              </b> <br /> <ul><li>Dyspepsia, Gastro-oesophageal reflux disease.</li></ul><br /><b>Dosage</b> <br /> <ul><li>Adult 1 cap bid or as directed by the physician. </li></ul><br />

Product Details:

Indications¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿
Peptic ulcer
NSAID-associated ulceration
H.pylori infection
Gastro-oesophageal reflux disease
Zollinger-Ellison syndrome
Prophylaxis of acid aspiration during general anaesthesia
Acid-related dyspepsia
Erosive oesophagitis

Dosage
Peptic ulcer
Adult 20 or 40 mg/day in severe cases for 4 wk (duodenal ulcer) or for 8 wk (gastric ulcer). Maintenance 10-20 mg/day. All doses to be taken once in the morning.

NSAID-associated ulceration
Adult 20 mg once in the morning.

H.pylori infection
Adult As triple therapy 20 mg bid or 40 mg once daily combined w/ amoxicillin 500 mg and metronidazole 400 mg both tid or combined w/ clarithromycin 250 mg and metronidazole 400 mg (or tinidazole 500 mg) both bid or combined w/ amoxicillin 1 g and clarithromycin 500 mg both bid. Duration 7 or 10 days. As 2-wk dual therapy 20 mg bid or 40 mg/day combined w/ either amoxicillin 750 mg to 1 g bid or w/ clarithromycin 500 mg tid.
Gastro-oesophageal reflux disease
Adult 20 mg/day for 4 wk may continue for another 4-8 wk if necessary. Refractory oesophagitis 40 mg/day. Maintenance 20 mg/day (after healing of oesophagitis); 10 mg/day (acid reflux). All doses to be taken once in the morning.
Child ¿¿¿1 yr 5-10 kg 5 mg; 10-20 kg 10 mg; >20 kg 20 mg. Double the dose if necessary. All doses to given once in the morning for 2-4 wk.

Zollinger-Ellison syndrome
Adult Initially, 60 mg once in the morning, adjust as required. Dose Range 20-120 mg/day. Doses >80 mg are administered in 2 divided doses.

Prophylaxis of acid aspiration during general anaesthesia
Adult 40 mg given in the evening and another 40 mg 2-6 hr pre-op.

Acid-related dyspepsia
Adult 10 or 20 mg once in the morning for 2-4 wk.

Erosive oesophagitis
Adult 20 mg/day for 4-8 wk. Maintenance of healing 20 mg/day for up to 12 mth. All doses to be taken once in the morning.
Elderly No dosage adjustment needed.

Product Details:

<b>Indications              </b> <br /> <ul><li>Gastro-oesophageal reflux disease</li><li>Gastric and duodenal ulcers</li><li>NSAID-associated ulceration</li><li>Zollinger-Ellison syndrome</li></ul><br /><b>Dosage</b> <br /> <ul><li>Gastro-oesophageal reflux disease; Gastric and duodenal ulcers; NSAID-associated ulceration</li><li>Adult 40 mg once daily infused over 20-30 min or slow inj over 5 min until oral admin is possible.</li></ul><br /><b>Zollinger-Ellison syndrome</b><br /> <ul><li>Adult Initially, 60 mg/day, adjust according to response. Daily doses >60 mg/day should be given in 2 divided doses.</li><li>Elderly No dosage adjustment needed.</li></ul>

Product Details:

Indications               <br />Zollinger-Ellison syndrome<br />Gastro-oesophageal reflux disease<br />Peptic ulcer<br /><br /><b>Dosage</b> <br /><br /><b>Zollinger-Ellison syndrome</b><br /> <ul><li>Adult 80 mg once or twice daily, adjusted up to 240 mg/day may be given in divided doses as slow inj or short-term infusion over 2-15 min. Convert to oral therapy as soon as possible.</li></ul><br /><b>Gastro-oesophageal reflux disease; Peptic ulcer</b> <ul><li>Adult 40 mg/day as slow inj or short-term infusion over 2-15 min. Convert to oral therapy as soon as possible.</li></ul><br /><b>Elderly</b> <br /> <ul><li>No dosage adjustment needed.</li></ul>

Product Details:

Indications

• Dyspepsia, Gastro-oesophageal reflux disease

Dosage

• Adult Per tablet/capsule contains pantoprazole 40 mg and domperidone 10 mg 1 tablet/capsule once daily

Product Details:

Indications

• Gastro-oesophageal reflux disease
• Peptic ulcer
• H.pylori infection
• Prophylaxis of NSAID-induced ulcers
• Zollinger-Ellison syndrome
• Erosive oesophagitis

Dosage

Gastro-oesophageal reflux disease

• Adult 20-40 mg once daily in the morning for 4 wk, increased to 8 wk if necessary. Maintenance 20-40 mg/day. Alternatively, 20 mg/day on recurring symptoms.
• Child ¿¿¿5 yr 15-40 kg 20 mg; >40 kg 40 mg All doses to be taken once daily in the morning.

Peptic ulcer

• Adult 40 mg once daily in the morning for 2-4 wk for duodenal ulceration or 4-8 wk for benign gastric ulceration.

H.pylori infection

• Adult 1-wk triple therapy 40 mg bid combined w/ clarithromycin 500 mg bid and amoxicillin 1 g bid or combined w/ clarithromycin 250 mg bid and metronidazole 400 mg bid.

Prophylaxis of NSAID-induced ulcers

• Adult 20 mg once daily in the morning.
• Zollinger-Ellison syndrome
• Adult Initially, 80 mg once daily in the morning, adjusted up to 240 mg/day if needed. Daily doses >80 mg should be given in 2 divided doses.

Erosive oesophagitis

• Adult 20-40 mg once daily in the morning for 4 wk, increased up to 16 wk if necessary. Maintenance 20-40 mg/day. Alternatively, 20 mg/day on recurring symptoms.
• Child ¿¿¿5 yr 15-40 kg 20 mg; >40 kg 40 mg. All doses to be taken once daily in the morning. Duration Up to 8 wk.
• Elderly No dosage adjustment needed.

Product Details:

Indications¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿

• Gastro-oesophageal reflux disease
• Zollinger-Ellison syndrome
• Peptic ulcer
• H.pylori infection
• Erosive oesophagitis

Dosage

Gastro-oesophageal reflux disease

• Adult 20 mg daily for 4-8 wk. Maintenance 10 or 20 mg/day. All doses to be taken once in the morning.
• Child ¿¿¿12 yr 20 mg once in the morning for up to 8 wk.

Zollinger-Ellison syndrome

• Adult Initially, 60 mg once in the morning, adjusted to max dose of 120 mg/day if needed. Daily doses >100 mg should be given in 2 divided doses.

Peptic ulcer

• Adult 20 mg once in the morning for 4-8 wk (duodenal ulcer) or for 6-12 wk (gastric ulcer).

H.pylori infection

• Adult 1-wk triple therapy 20 mg bid combined w/ clarithromycin 500 mg bid and amoxicillin 1 g bid or combined w/ clarithromycin 250 mg bid and metronidazole 400 mg bid.

Erosive oesophagitis

• Adult 20 mg/day for 4-8 wk. May continue for another 8 wk if healing is incomplete. Maintenance 10 or 20 mg/day. All doses to be taken once in the morning.
• Elderly No dosage adjustment needed.

Product Details:

Indications

• Gastro-oesophageal reflux disease
• Zollinger-Ellison syndrome
• Peptic ulcer
• H.pylori infection

Dosage

• Recommended dose is I.V. administration of the content of one vial (20 mg rabeprazole) once daily.
• Parenteral routes of administration other than I.V. are not recommended.
• Injection The content of the vial needs to be reconstituted with 5 ml sterile water for injection, which should be given slowly over 5-15 minutes.
• Infusion For I.V. infusion, the reconstituted solution should be further diluted and administered as a short-term infusion over 15-30 minutes.

Product Details:

Indications¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿

• Gastro-oesophageal reflux disease
• Zollinger-Ellison syndrome
• Peptic ulcer
• H.pylori infection

Dosage

Adults/elderly

• Active Duodenal Ulcer and Active Benign Gastric Ulcer The recommended oral dose for both active duodenal ulcer and active benign gastric ulcer is 20mg to be taken once daily in the morning.
• Erosive or Ulcerative Gastro-Oesophageal Reflux Disease (GORD) The recommended oral dose for this condition is 20mg to be taken once daily for four to eight weeks.
• Gastro-Oesophageal Reflux Disease Long-term Management (GORD Maintenance) For long-term management, a maintenance dose of Rabeprazole Sodium20mg or 10mg once daily can be used depending upon patient response.
• Symptomatic treatment of moderate to very severe gastro-oesophageal reflux disease (symptomatic GORD) 10mg once daily in patients without oesophagitis. If symptom control has not been achieved during four weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using an on-demand regimen taking 10mg once daily when needed.
• Zollinger-Ellison Syndrome The recommended adult starting dose is 60mg once a day. The dose may be titrated upwards to 120mg/day based on individual patient needs. Single daily doses up to 100mg/day may be given. 120mg dose may require divided doses, 60mg twice daily. Treatment should continue for as long as clinically indicated.
• Renal and hepatic impairment No dosage adjustment is necessary for patients with renal or hepatic impairment.
• Children Rabeprazole Sodium is not recommended for use in children, as there is no experience of its use in this group.

Product Details:

Indications

• Dissolution of cholesterol-rich gallstones
• Primary biliary cirrhosis
• Prophylaxis of gallstones in patients undergoing rapid weight loss

Dosage

Dissolution of cholesterol-rich gallstones

• Adult 8-12 mg/kg once daily at bedtime or in 2 divided doses continued for 3-4 mth after radiological disappearance of gallstones. Duration of treatment Up to 2 yr. Obese patients Up to 15 mg/kg daily.

Primary biliary cirrhosis

• Adult 10-16 mg/kg daily in 2-4 divided doses, may be taken once daily in the evening after the 1st 3 mth.

Prophylaxis of gallstones in patients undergoing rapid weight loss

• Adult 300 mg bid.